A significant recent advance in t e diagnosis on heart disease has resulted f om the d velopement and widespread application of ethods to quantitate levels of enzyme activities, especil ly LDH and LDH isoenzymes in the blood or se um of m. n.
Characteristic alteration n the di? tribution of isoenzymes of lactic dehydro.enase we, e found in a variety of diseases associat; d with elevated serum, LDH levels, which genera ly reflec,ed the sites of organ injury.
The evolution of the LL IH1-abnor- ality as a ref= lection of myocardial infarction wer- studied extensively.
With certain reservation, it prov d to be a more sensitive index of heart in ury tha other enzyme assays or the eletrocardiogram.
This report will describe the DH ..,isoenzyme activity alterations in m ocardiol infarction and discuss the usefullness of t~liist proce.ure in the diagnosis and in following th~ clinical ourse of illness,
Serum LDH isoenzyme fraction were separated by agar gel electrophoresis.
Eight patients with acute ?myoc. rdial infarction and twelve patients with congesti e. heart, failure were studied.
The results were as follows:
1) In patients with acute ´myocardial infarction the activity of total . LDH and LDH1 were smarlidly increased.
Total LDH returned to normal range on the 710 days of clinical onset, but LDH1 remained significantly high and altered ratio of LDH1/LDH2 persisted after 15 days of clinical onset.
2) In patients with congestive herat failure, serum total LDH and LDH1 was slightly increased.
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